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One Vaccine Could Tackle Millions of Childhood Infections
An international study led by the Wellcome Sanger Institute and collaborators analyzed nearly 10,000 Haemophilus influenzae genomes, uncovering low global genetic diversity and extensive antibiotic resistance.
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Antiviral Approach Uses Decoys To Block Lethal Viruses
Washington University researchers discovered how yellow fever and tick-borne encephalitis viruses enter human cells and created decoy molecules that block infection, paving the way for new antiviral therapies.
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Muscle Regeneration Enhanced by JAK2 Inhibition in Stem Cells
Study shows that blocking a protein can yield more and more potent cells for regenerating diseased muscle.
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New Dual-Action Vaccine Combats Merkel Cell Carcinoma
Yale researchers have developed a new vaccine that does double duty against a rare and aggressive skin cancer by targeting the protein essential to tumor cell growth and by adding a key signal to boost the immune system response.
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Intracellular GPCR Targeting Unlocks New Biased Therapies
New study shows that targeting an oft-drugged family of cell membrane receptors with biased modulators can expand potential drug targets and reduce side effects.
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Raman Spectroscopy-Based Tool Monitors Vaccine Quality During Production
Enhancing continuous manufacturing of vaccines, researchers innovate a Raman spectroscopy tool for efficient quality control in production.
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Harnessing P-Bodies To Direct Stem Cell Fate
By modulating P-bodies, cytoplasmic structures containing RNA and RNA-binding proteins, it may be possible to guide cells toward clinically valuable types, advancing regenerative medicine and infertility research.
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Why Vaccines Work Less Effectively in Older Adults
Allen Institute scientists are learning why vaccines can trigger a weaker response in older adults, around age 65, and what can be done to improve them. These insights open the door to designing more effective vaccines.
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Nanostructured Chemotherapy Delivery Shows 20,000x Effectiveness in AML
In a promising advance for cancer treatment, Northwestern University scientists have re-engineered the molecular structure of a common chemotherapy drug, making it dramatically more soluble and effective and less toxic.
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Why Some Breast Cancers Are Resistant to Antibody–Drug Conjugates
New research has uncovered a built-in resistance mechanism to antibody–drug conjugates in some breast cancers and identified a way to overcome this.
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