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Vaccine vials on a production line, representing child vaccine development in a lab setting.
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One Vaccine Could Tackle Millions of Childhood Infections

An international study led by the Wellcome Sanger Institute and collaborators analyzed nearly 10,000 Haemophilus influenzae genomes, uncovering low global genetic diversity and extensive antibiotic resistance.
Mmouse neurons and their cell nuclei (purple and blue). On the left, infection with tick-borne encephalitis virus is visible in green. On the right, mouse neurons missing a key entry receptor are protected from infection, showing no green.
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Antiviral Approach Uses Decoys To Block Lethal Viruses

Washington University researchers discovered how yellow fever and tick-borne encephalitis viruses enter human cells and created decoy molecules that block infection, paving the way for new antiviral therapies.
Human muscle cells derived from the Caputo et al. optimized protocol efficiently regenerate muscle tissue upon transplantation in mice.
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Muscle Regeneration Enhanced by JAK2 Inhibition in Stem Cells

Study shows that blocking a protein can yield more and more potent cells for regenerating diseased muscle.
A syringe filled with yellow fluid, held by a gloved hand.
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New Dual-Action Vaccine Combats Merkel Cell Carcinoma

Yale researchers have developed a new vaccine that does double duty against a rare and aggressive skin cancer by targeting the protein essential to tumor cell growth and by adding a key signal to boost the immune system response.
Blue brug capsule with one half as a circuit board and the other with small brains.
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Intracellular GPCR Targeting Unlocks New Biased Therapies

New study shows that targeting an oft-drugged family of cell membrane receptors with biased modulators can expand potential drug targets and reduce side effects.
Vials of vaccines on a production line for continuous manufacturing.
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Raman Spectroscopy-Based Tool Monitors Vaccine Quality During Production

Enhancing continuous manufacturing of vaccines, researchers innovate a Raman spectroscopy tool for efficient quality control in production.
Close up illustration of many pink and purple colored stem cells, floating against a dark red background.
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Harnessing P-Bodies To Direct Stem Cell Fate

By modulating P-bodies, cytoplasmic structures containing RNA and RNA-binding proteins, it may be possible to guide cells toward clinically valuable types, advancing regenerative medicine and infertility research.
Older adult wearing face mask receiving vaccination.
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Why Vaccines Work Less Effectively in Older Adults

Allen Institute scientists are learning why vaccines can trigger a weaker response in older adults, around age 65, and what can be done to improve them. These insights open the door to designing more effective vaccines.
Multiple microscopic cancer cells.
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Nanostructured Chemotherapy Delivery Shows 20,000x Effectiveness in AML

In a promising advance for cancer treatment, Northwestern University scientists have re-engineered the molecular structure of a common chemotherapy drug, making it dramatically more soluble and effective and less toxic.
Treatment-resistant breast cancer cells are illuminated in red amongst other cancer cells in green and blue.
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Why Some Breast Cancers Are Resistant to Antibody–Drug Conjugates

New research has uncovered a built-in resistance mechanism to antibody–drug conjugates in some breast cancers and identified a way to overcome this.
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