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Antibody Therapy Breaks Immune Evasion in Pancreatic Cancer
Study reveals how pancreatic tumors evade immunity using a sugar disguise, and how a new antibody restores immunity in mice.
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Genomic Copy Number Variants Help Melanoma Develop Immunotherapy Resistance
Researchers reveal how melanoma evolves to resist immunotherapy, identifying a potential treatment strategy.
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Circulating Tumor Cells Could Help Stratify Breast Cancer Treatment
Some women undergo unnecessary mastectomy and chemotherapy, but a "labyrinth in a chip" could reveal which cancers need aggressive treatments.
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Reprogramming Myeloid Cells Enhances the Power of T-Cell Immunotherapy
Researchers have discovered that targeting PD-L1 recycling in myeloid cells enhances T-cell activation and boosts the effects of checkpoint blockade therapies. A new antibody, H1A, shows promise for improving treatment outcomes.
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More Than Half of Americans Underestimate the Link Between Alcohol and Cancer
A new study has revealed widespread misbeliefs around the cancer risks of consuming alcohol.
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New Dual-Action Vaccine Combats Merkel Cell Carcinoma
Yale researchers have developed a new vaccine that does double duty against a rare and aggressive skin cancer by targeting the protein essential to tumor cell growth and by adding a key signal to boost the immune system response.
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New Chemotherapy Agent LiPyDau Overcomes Drug-Resistant Cancer
Researchers have developed a groundbreaking new chemotherapeutic agent, LiPyDau, which shows remarkable efficacy against multiple tumor types in preclinical studies.
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Additional Testing in Renal Cell Cancer Patients With TRIM63 Overexpression May Improve Diagnosis
A University of Michigan Health study finds that testing for TRIM63 overexpression in renal cell carcinoma can reveal previously undetected mutations, potentially opening the door to more treatment options for patients.
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"Under-Appreciated" Gene Mutation Blocks Immune Checkpoint Inhibitors
An under-appreciated cancer mutation has been found to block immune checkpoint inhibitor drugs, offering a new approach to treating "cold" tumors.
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Gut Bacteria Metabolites Linked to Cell Growth and Cancer Suppression
Bacterial metabolites queuine and preQ1 have been found to directly regulate protein synthesis in human cells, promoting or suppressing cell growth with implications for cancer therapy.
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