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ASO Drug Targets ALS and FTD Neuronal Hyperexcitability

Northwestern researchers were able to calm overactive neurons and restore neuronal activity, which could potentially slow the progression of disease.
Woman sitting in dark corridor with head in hands.
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Antidepressant Fluoxetine Found To Rewire the Brain’s Energy System, Boosting Plasticity

New research reveals that the antidepressant fluoxetine does more than raise serotonin levels – it changes how brain cells use energy and rebuild their connections, potentially reopening the brain’s capacity to adapt.
Illustration of obese individual, drug pen, drug capsules, tape measure and scales.
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Obesity Care Divide Grows as Mounjaro Access Remains Limited

Treatment for obesity in the UK could become a “two-tier system” where the most vulnerable patients miss out altogether.
Individual holding a weight loss drug pen.
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GLP-1 Drugs Cut Weight Significantly, But Long-Term Data Limited

Three new Cochrane reviews find evidence that GLP-1 drugs result in clinically meaningful weight loss, but industry-funded studies raise questions.
A cobra in the grass.
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First Lab-Made Antivenom Protects Against Africa’s Deadliest Snakes

Scientists have co-developed the world’s first product-ready, lab-produced, recombinant snakebite antivenom that protects against many of Africa’s most dangerous snakes and outperforms existing antivenoms.
An orange prescription pill bottle spills multicolored pills onto a blue background.
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Common Antidepressant Improves Core Depression Symptoms in Just Two Weeks

Sertraline contributes to a modest improvement in core depression and anxiety symptoms within two weeks, a new analysis has found.
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New Chemotherapy Agent LiPyDau Overcomes Drug-Resistant Cancer

Researchers have developed a groundbreaking new chemotherapeutic agent, LiPyDau, which shows remarkable efficacy against multiple tumor types in preclinical studies.
Blue brug capsule with one half as a circuit board and the other with small brains.
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Intracellular GPCR Targeting Unlocks New Biased Therapies

New study shows that targeting an oft-drugged family of cell membrane receptors with biased modulators can expand potential drug targets and reduce side effects.
Cancer cells, with proteins labelled in blue, purple and green.
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"Under-Appreciated" Gene Mutation Blocks Immune Checkpoint Inhibitors

An under-appreciated cancer mutation has been found to block immune checkpoint inhibitor drugs, offering a new approach to treating "cold" tumors.
Vials of vaccines on a production line for continuous manufacturing.
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Raman Spectroscopy-Based Tool Monitors Vaccine Quality During Production

Enhancing continuous manufacturing of vaccines, researchers innovate a Raman spectroscopy tool for efficient quality control in production.
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