News

Researchers identified how leptin, a hormone from fat cells, fuels estrogen receptor-positive breast cancer. The study found leptin activates the enzyme SCD, boosting cancer cell growth and energy production.

Monash University researchers used CRISPR or a PTPN2 inhibitor to enhance CAR T cell function against solid tumors. Blocking PTPN2 improved T cell persistence and tumor killing in preclinical models, creating long-lived, stem-like CAR T cells.

New research has identified two complementary mechanisms that enable metastatic colorectal cancer to block the immune system.

Researchers used spatial transcriptomic mapping to reveal that inflammation drives the earliest stages of lung cancer. They identified highly inflamed regions containing tumor-associated cells.

New research has found that commonly used heartburn and blood pressure medications may interact with cancer therapies, influencing side effects and survival outcomes.

A new molecule developed by researchers at Oregon Health & Science University offers a promising avenue to treat intractable cases of triple-negative breast cancer — a form of cancer that is notoriously aggressive and lacks effective treatments.

Researchers discovered that some p53 mutations, particularly R273H, overstimulate DNA replication and trigger immune activation through the cGAS-STING pathway. These tumors responded better to immunotherapy in mouse models.

Researchers uncovered 117 enzymes that modify RNA polymerase II, the key enzyme that transcribes DNA into RNA. The study revealed that even cell-surface kinases like EGFR act within the nucleus to regulate transcription.

A study reveals that NUDT5 regulates purine production, the process that builds DNA, without using its enzymatic activity. Instead, NUDT5 acts as a molecular scaffold that halts DNA synthesis when purine levels are high.

By employing a technique called Nanoendoscopy-AFM, which inserts a nanoneedle probe directly into cells, scientists revealed how cancer cell nuclei stiffen or soften depending on chromatin structure and environmental conditions.